YANG LAB
2021 ~ present
Yuan S, Stewart KS, Yang Y, Abdusselamoglu MD, Parigi SM, Feinberg TY, Tumaneng K, Yang H, Levorse JM, Polak L, Ng D, Fuchs E. Ras drives malignancy through stem cell crosstalk with the microenvironment. Nature 2022 Nov 30. doi: 10.1038/s41586-022-05475-6.
Shin JM, Lee YY, Hong D, Jung KE, Seo YJ, Kim CD, Yang H, Lee Y. Baricitinib Attenuates IFN-γ and Polyinosinic:polycytidylic Acid‒Induced Mitochondrial Damage and Inflammasome Activation in Human Keratinocytes. J Invest Dermatol. 2022 Aug 28;S0022-202X(22)01879-6.
Park SE, Lee D, Jeong JW, Lee SH, Park SJ, Ryu J, Oh SK, Yang H*, Fang S*, Kim S*. Gut Epithelial Inositol Polyphosphate Multikinase Alleviates Experimental Colitis via Governing Tuft Cell Homeostasis. Cell Mol Gastroenterol Hepatol. 2022 Aug 19;14(6):1235-1256. (*Co-corresponding authors)
Kim HJ, Shim JH, Park JH, Shin HT, Shim JS, Jang KT, Park WY, Lee KH, Kwon EJ, Jang HS, Yang H, Lee JH, Yang JM, Lee D. Single-cell RNA sequencing of human nail unit defines RSPO4 onychofibroblasts and SPINK6 nail epithelium. Commun Biol. 2021 Jun 7;4(1):692.
2015 ~ 2020
Adam RC*, Yang H*, Ge Y, Infarinato NR, Gur-Cohen S, Miao Y, Wang P, Zhao Y, Lu CP, Kim JE, Ko JY, Paik SS, Gronostajski RM, Kim J, Krueger JG, Zheng D, Fuchs E. NFI transcription factors provide chromatin access to maintain stem cell identity while preventing unintended lineage fate choices. Nature Cell Biology, 2020;22(6), 640-650. (*Co-first authors)
Ge Y, Miao Y, Gur-Cohen S, Gomez N, Yang H, Nikolova M, Polak L, Hu Y, Verma A, Elemento O, Krueger JG, Fuchs E. The Aging Skin Microenvironment Dictates Stem Cell Behavior. PNAS, 2020;117(10):5339-5350
Gur-Cohen S, Yang H, Baksh SC, Miao Y, Levorse J, Kataru RP, Liu X, Cruz-Racelis JD, Mehrara Babak, Fuchs E. Stem cell-driven lymphatic remodeling coordinates tissue regeneration. Science, 2019;366(6470): 1218-1225.
Miao Y, Yang H, Levorse J, Yuan S, Polak L, Sribour M, Singh B, Rosenblum M, Fuchs E. Adaptive immune resistance emerges from tumor-Initiating stem cells. Cell, 2019;177(5):1172-1186.
Adam RC*, Yang H*, Ge Y, Lien WH, Wang P, Zhao Y, Polak L, Levorse J, Baksh SC, Zheng D, Fuchs E. Temporal Layering of Signaling Effectors Drives Chromatin Remodeling during Hair Follicle Stem Cell Lineage Progression. Cell Stem Cell, 2018;22(3), 398-413 (*Co-first authors)
Ge Y, Gomez NC, Adam RC, Nikolova M, Yang H, Verma Akanksha, Lu CP, Polak L, Yuan S, Elemento O, Fuchs E. Stem cell lineage infidelity drives wound repair and cancer. Cell 2017;169(4), 636-650
Yang H, Adam RC, Ge Y, Hua ZL, Fuchs E. Epithelial-mesenchymal micro-niches govern stem cell lineage choices. Cell 2017;169(3), 483-496
Yang H*, Schramek D*, Adam RC, Keyes BE, Wang P, Zheng D, Fuchs E. ETS family transcriptional regulators drive chromatin dynamics and malignancy in squamous cell carcinomas. eLIFE 2015;4, e10870 (*Co-first authors)
Adam RC, Yang H, Rockowitz S, Larsen SB, Nikolova M, Oristian DS, Polak L, Kadaja M, Asare A, Zheng D, Fuchs E. Pioneer factors govern super-enhancer dynamics in stem cell plasticity and lineage choice. Nature 2015;512(7552), 366-70
2009 ~ 2014
Lee SH*, Lee S*, Yang H*, Song S, Kim K, Saunders TL, Yoon JK, Koh GY, Kim I. The Notch pathway targets proangiogenic regulator Sox17 to restrict angiogenesis. Circulation Research. 2014;115(2), 215-226 (*Co-first authors)
Kim C*, Yang H*, Fukushima Y*, Saw PE, Lee J, Park J, Park I, Jung J, Kataoka H, Lee D, Heo WD, Kim I, Jon S, Adams RH, Nishikawa S, Uemura A, Koh GY. Vascular RhoJ is an effective and selective target for tumor angiogenesis and vascular disruption. Cancer Cell. 2014;25(1), 102-117 (*Co-first authors)
Yang H*, Lee S*, Lee SJ, Kim K, Yang Y, Kim JH, Adams RH, Wells JM, Morrison SJ, Koh GY, Kim I. Sox17 promotes tumor angiogenesis and destabilizes tumor vessels in mice. Journal of Clinical Investigation. 2013;123(1), 418-431 (*Co-first authors)
Yang H*, Kim C*, Kim MJ, Schwendener RA, Alitalo K, Heston W, Kim I, Kim WJ, Koh GY. Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer. Mol Cancer. 2011; 10:36 (*Co-first authors)
Kataru RP, Jung K, Jang C, Yang H, Schwendener RA, Baik JE, Han SH, Alitalo K, Koh GY. Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution. Blood. 2009; 28:113(22), :5650-5659